CD255 抗体
This anti- antibody is a 小鼠 单克隆 antibody detecting in FACS, IHC 和 Func. Suitable for 人. This Primary Antibody has been cited in 6+ publications.
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(6 references)Quick Overview for CD255 抗体 (ABIN2749023)
抗原
CD255
适用
人
宿主
小鼠
克隆类型
单克隆
标记
非结合性
应用范围
Flow Cytometry (FACS), Immunohistochemistry (IHC), Functional Studies (Func)
克隆位点
CARL-1
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原理
- Anti-Hu CD255 Purified Low Endotoxin
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特异性
- The mouse monoclonal antibody CARL-1 recognizes an extracellular epitope of CD255 / TWEAK, a type II transmembrane protein of the TNF superfamily able to induce apoptosis weakly in many cell types.
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交叉反应 （详细）
- Human
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纯化方法
- Purified by protein-A affinity chromatography.
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纯度
- > 95 % (by SDS-PAGE)
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内毒素水平
- Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
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免疫原
- human CD255-transfected 2PK-3 cells
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亚型
- IgG3 kappa
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anti-CD255 antibody
适用: 人 FACS, IHC 宿主: 小鼠 Monoclonal CARL-1 unconjugated
anti-CD255 antibody (PE)适用: 人 FACS 宿主: 小鼠 Monoclonal CARL-1 PE
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应用备注
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Functional application: Neutralization.
Flow cytometry: Recommended dilution: 1-4 μg/mL -
限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Tris buffered saline (TBS), pH 8.0
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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: "Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer." in: Experimental and therapeutic medicine, Vol. 2, Issue 1, pp. 103-108, (2012) (PubMed).
: "Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway." in: The Journal of biological chemistry, Vol. 285, Issue 23, pp. 17432-41, (2010) (PubMed).
: "Proinflammatory effects of tumour necrosis factor-like weak inducer of apoptosis (TWEAK) on human gingival fibroblasts." in: Clinical and experimental immunology, Vol. 146, Issue 3, pp. 540-9, (2006) (PubMed).
: "TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation." in: The Journal of biological chemistry, Vol. 278, Issue 38, pp. 36005-12, (2003) (PubMed).
: "Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 1, pp. 341-8, (2002) (PubMed).
: "Involvement of TWEAK in interferon gamma-stimulated monocyte cytotoxicity." in: The Journal of experimental medicine, Vol. 192, Issue 9, pp. 1373-80, (2000) (PubMed).
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: "Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer." in: Experimental and therapeutic medicine, Vol. 2, Issue 1, pp. 103-108, (2012) (PubMed).
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- CD255
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背景
- TNF superfamily member 12,CD255 / TWEAK (TNF-related weak inducer of apoptosis), a type II transmembrane protein expressed as membrane-bound and secreted form, can induce apoptosis in many tissues and cell lines through its receptor CD266 / TWEAK R. On the other hand, in endothelial cells this interaction can induce proliferation and promote angiogenesis including neovascularization of tumours. CD255 can act in a juxtacrine manner to initiate cellular responses, and induces secretion of pro-inflammatory cytokines. Besides CD266, CD255 may also bind to DR3.,TNFSF12, APO3L, DR3LG, TWEAK, TNLG4A
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基因ID
- 8742
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UniProt
- O43508
抗原
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